Synthesis and Biological Evaluation of Some Novel Arylidene Hydrazides Derivatives

There has been considerable interest in the development of novel compounds with anticonvulsant, antioxidant, antibacterial, and antifungal activities. The present study explores antimicrobial activity some new arylidene hydrazide derivatives correlates effect on potency by varying substituents part arylidine hydrazide. Hydrazones possessing an azomethine–NHN=CH- proton constitute important class for drug developments; therefore, a series hydrazides were synthesized various aromatic aldehydes/ketones. synthesis title was affected as outlined scheme. In this scheme O-chloro benzoic acid reaction aniline through Ullmann Reaction gave N-phenyl anthranilic acid. esterification product followed hydrazine hydrate yielded 2-phenyl amino These give compounds. A total 11 synthesized. synthetic methods used are simple, rapid, economical found to be accurate reproducible. All intermediates characterized running TLC, determining M.P. spectral studies such IR 1H-NMR. showed mild-to-moderate antibacterial against Gram-positive Bacillus subtilis (MTCC441), cereus (MTCC-7190) Gram-negative Escherichia coli Candida albicans Aspergillus fumigates (ATTC 9197). bio-screening data revealed that 4b, 4f, 4g, 4h, 4j moiety exhibited good all where 4a 4c activity. Among compounds, antioxidant too.